The malaria parasite has been studied for decades, but surprisingly, little is known about how it behaves in humans to cause disease.

In a groundbreaking study published November 28, 2007 in the advance online edition of Nature, an international research team has for the first time measured which of the parasite’s genes are turned on or off during actual infection in humans, not in cell cultures, unearthing surprising behaviors and opening a window on the most critical aspects of parasite biology.

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